Progress and challenges in the synthesis of sequence controlled polysaccharides

• Giulio Fittolani,
• Theodore Tyrikos-Ergas,
• Denisa Vargová,
• Manishkumar A. Chaube and
• Martina Delbianco

Beilstein J. Org. Chem. 2021, 17, 1981–2025, doi:10.3762/bjoc.17.129

• , fluorine, and carboxymethyl groups, prevented the formation of insoluble aggregates by disrupting hydrogen-bond networks. Dramatic differences in the conformation (e.g., radius of gyration and glycosidic bond conformation) and aggregation behaviour (i.e., crystallinity and solubility) were observed for

Aggregation behaviour of a single-chain, phenylene-modified bolalipid and its miscibility with classical phospholipids

• Simon Drescher,
• Vasil M. Garamus,
• Christopher J. Garvey,
• Annette Meister and
• Alfred Blume

Beilstein J. Org. Chem. 2017, 13, 995–1007, doi:10.3762/bjoc.13.99

• -Mothes-Str. 3, 06120 Halle (Saale), Germany 10.3762/bjoc.13.99 Abstract In the present work, we describe the synthesis of a single-chain, phenylene-modified bolalipid with two phosphocholine headgroups, PC-C18pPhC18-PC, using a Sonogashira cross-coupling reaction as a key step. The aggregation behaviour

• -C18pPhC18-PC is partially miscible with saturated phosphatidylcholines; however, closed lipid vesicles with an increased thermal stability were not found. Instead, bilayer fragments and disk-like aggregates are formed. Keywords: aggregation behaviour; bolaamphiphiles; bolalipids; membrane lipids; mixing

• dependency on both the aggregation behaviour of the pure bolalipid and the miscibility with bilayer-forming phospholipids. In this study, we investigated the aggregation behaviour of PC-C18pPhC18-PC in aqueous suspension by means of DSC, TEM, Fourier-transform infrared (FTIR) spectroscopy, and small angle

A new class of organogelators based on triphenylmethyl derivatives of primary alcohols: hydrophobic interactions alone can mediate gelation

• Wangkhem P. Singh and
• Rajkumar S. Singh

Beilstein J. Org. Chem. 2017, 13, 138–149, doi:10.3762/bjoc.13.17

• -stacking, donor–acceptor interaction, electrostatic, metal coordination, hydrophobic forces or van der Waals’ interactions [4][5][6]. We know a great deal about the aggregation behaviour of gelator molecules from many studies conducted during the past several years. However, rational design and accurate

Aggregation behaviour of amphiphilic cyclodextrins: the nucleation stage by atomistic molecular dynamics simulations

• Giuseppina Raffaini,
• Antonino Mazzaglia and
• Fabio Ganazzoli

Beilstein J. Org. Chem. 2015, 11, 2459–2473, doi:10.3762/bjoc.11.267

• recognize cells by exposing receptor-targeting groups on the surface of the nanoassembly [30]. Because of these promising results, we have begun to investigate the aggregation behaviour of an aCD model compound by atomistic computer simulation to clarify the early stages of self-assembly, in particular the